Main Street Cannabis is a licensed dispensary in Pine Ridge, South Dakota.
4.8
78 reviews
Nathan S.
September 18, 2025
I bought 2 carts and they both stopped working after 5 hits. Complete waste of money. I bought a gram of wax there and that was good quality with a really good taste. A bit pricey. I don't think I'll be going back though
John Escott
July 12, 2025
Spectacular customer service and amazing inventory. Highly recommend staff and services available!
Chris Cargill
June 18, 2025
The Carts have very good oil in them. but for some reaon the carts burn out with anywhere from 25% - 75% of the oil still remaining in the cart. I have bought an "Empty Cart" and I dump the oil into the High Quality Cartridge, when their cartridge burns up, and so far the Cartridges I bought have not burned up, and have no problem burning the oil. Meaning it's the quality of the cartridges that is causing this. My friend works security, and he had the same problem happen with Every cartridge he bought also. I have only gotten a handful from MS that burned all the way to empty. Here lately the last 7/7 have burnt up, and stoped working, literally only 1 out of 15 of the last cartridges I bought worked all the way to empty! Main Street has had different "style" cartridges, but if they ALL come from the same supplier, they will still be LOW QUALITY CARTRIDGES that can't burn off high quality Oil. I have never had this problem from high quality oil. The oil is ALMOST good enough to STILL get 5 Stars BUT, EVERYTIME I buy a cart from here I have to heat the oil, and somehow dump it into another cartridge without making a mess. The style cartridges main Street uses, also makes this harder because they don't screw off. This means you have to attempt to break the mouthpiece off, WITHOUT BREAKING the tank, and leaking oil everywhere. also need a pile of weed underneath while transferring in case any oil spills at least I can smoke it off the weed. I also need to go buy a Different EMPTY cartridge (Not that easy to find! Im going to have to drive to the nearest LARGE CITY) . Its a mess. One of the main reasons I Pay 55 dollars for a cart is because I don't have to do ALL THIS STUFF, OR BREAK UP WEED!
Kathy Petersen
July 3, 2024
I've been to many dispensaries in the country, and I've always felt uncomfortable at them, which is interestingly strangely uncharacteristic of the nature of the business. HOWEVER, I walked in to Main Street Cannabis and the security guy was so friendly and chill, and the lady at the counter was super friendly, like I was talking to a pal. Prices are a little on the high end, the place is very clean, open when they said they were (we stopped at Warpath Cannabis first, and the doors were locked and the person at the auto repair shop, that seems to be connected, was of no help... Google said they were open) .....and there's a decent variety. I would recommend Main Street.
Erikka Lynn
October 23, 2022
Such a nice shop and they have great prices! Can't wait to come back!! The guy working the counter was also super helpful! (:
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Levoit Core 300-P
143 CFM · 219 sq ft
$80–$110
Coway Airmega AP-1512HH
246 CFM · 361 sq ft
$160–$210
Austin Air HM400
400 CFM · 1,500 sq ft
$475–$595
Only South Dakota residents with medical cards may purchase. No out-of-state reciprocity. Main Street Cannabis is a medical dispensary, so a valid medical card is required for purchases.
In South Dakota, medical customers can purchase up to 3 oz per calendar year (increased amounts available with physician authorization). Main Street Cannabis may have additional product-specific limits — check with the dispensary for details.
Main Street Cannabis accepts cash as well as Debit.
Main Street Cannabis does not currently list delivery as an option. Available options include in-store.
Main Street Cannabis is located at 99 East Main Street, Pine Ridge, SD 57770. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
Pine Ridge, SD
Pine Ridge, SD
Pine Ridge, SD
Last updated January 15, 2026
South Dakota legalized medical marijuana in 2020 through Initiated Measure 26. A simultaneous recreational measure (Amendment A) was passed by voters but struck down by the state Supreme Court. Medical dispensaries are operational.
Medical: 18+
Med: 3 oz per calendar year (increased amounts available with physician authorization)
Prohibited.
Medical patients may grow up to 3 plants if they live more than 50 miles from a dispensary.
Not allowed
Medical: standard state sales tax (4.5%) plus applicable municipal taxes.
Only South Dakota residents with medical cards may purchase. No out-of-state reciprocity.
Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.
