Sanctuary Cannabis Orlando I-Drive Dispensary is a highly-rated medical marijuana dispensary in Orlando, Florida, with a 4.9-star average across 1,878+ customer reviews. The shop carries a full selection of flower, edibles, and concentrates. Sanctuary Cannabis Orlando I-Drive Dispensary offers in-store shopping. Known for being boutique, organic. Customers frequently mention i arrived 3 minutes before closing my and te staff here still serviced me with a bright smile.
Sanctuary Cannabis Orlando I-Drive Dispensary is a medical-only dispensary. You must have a valid Florida medical marijuana card to purchase here. Get approved online in about 20 minutes.
4.9
1,878 reviews
William Rodriguez
January 17, 2026
Today is my third time going to the store. I must say, I have a great experience since the first time . The staff is great team the took time to help me out how to register on line, explain me How everything work out, Plus the find out the right flower. Already tried different ones and all the flowers good 👍🏼😊💯. thanks to Mario and Keren👏🏼👏🏼👏🏼been so patient and great customer service 💯✍🏼
Joshua Melton
December 22, 2025
As a first time, customer and patient I have tons of questions and I was pleased to have them all answered here in a timely manner, and I felt comfortable the whole experience. It’s nice to have like-minded souls around you. The quality and Personable experience made me feel welcomed.
Desmond Kelly
November 6, 2025
I arrived 3 minutes before closing my and te staff here still serviced me with a bright smile! I am back today to say thank you and to shop some more. I will return and share the good news about this facility. Outstanding staff!
Javier Sarmiento
August 16, 2025
Super friendly staff and great service! They made me feel welcome right away and helped me find exactly what I needed. Awesome selection and a really comfortable vibe — definitely my go-to dispensary in Orlando.
Ross Barnett
August 11, 2025
Finally, after so many stories and being told “you haveee to try Sanctuary”, I’m a happy customer. I shopped for my first time with Maddie! She was super cool and easy to talk to about options. Thrilled with my Oishii strain and Lazy Buns strain. Oishii tastes like a candied fruit while Lazy Buns has the taste of a sweet vanilla and lemon cream! Thanks Maddie, for helping me get some tasty stuff at a great price. 5 eighths for $58 and a free chocolate bar, to me, is phenomenal. I didn’t even have to use my 60% off first time patient discount because the deals were so good. I was told I can use it next time I’m in. I will be back for more whenever I’m in the area! 👏🏻
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Florida does not sell recreational cannabis. The state offers a temporary 210-day medical marijuana card to seasonal residents who have a Florida physician certification, but standard tourists cannot purchase cannabis. Sanctuary Cannabis Orlando I-Drive Dispensary is a medical dispensary, so a valid medical card is required for purchases.
In Florida, medical customers can purchase up to 2.5 oz of smokable flower per 35 days, plus separate allowances for other product types as determined by physician. Sanctuary Cannabis Orlando I-Drive Dispensary may have additional product-specific limits — check with the dispensary for details.
Sanctuary Cannabis Orlando I-Drive Dispensary is cash only. Check with the dispensary for nearby ATM locations.
Sanctuary Cannabis Orlando I-Drive Dispensary does not currently list delivery as an option. Available options include in-store.
Sanctuary Cannabis Orlando I-Drive Dispensary is located at 5381 International Drive, Orlando, FL 32819. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
You need a Florida medical marijuana card to purchase from dispensaries in this state. The whole process can be completed with one in-person visit.
✓ Board-certified physicians · ✓ 4.8★ rated · ✓ 500,000+ patients approved
Get My Florida Medical Card
Orlando, FL
Orlando, FL
Orlando, FL
Last updated January 15, 2026
Florida legalized medical marijuana in 2016 through Amendment 2 with 71% voter approval. Recreational cannabis remains illegal — a 2024 ballot measure (Amendment 3) received 57% but fell short of the required 60% supermajority. Florida has one of the largest medical marijuana programs in the country with over 800,000 registered patients.
Medical: 18+
Med: 2.5 oz of smokable flower per 35 days, plus separate allowances for other product types as determined by physician
Prohibited. Cannabis cannot be consumed in public places. Smokable flower cannot be consumed in any enclosed indoor workplace. Must be consumed at a private residence.
Not allowed. Home cultivation is illegal, including for medical patients.
Allowed
Medical cannabis is exempt from state sales tax in Florida.
Florida does not sell recreational cannabis. The state offers a temporary 210-day medical marijuana card to seasonal residents who have a Florida physician certification, but standard tourists cannot purchase cannabis.
Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.
