253 Farmacy is a premier weed dispensary located in Amherst, Massachusetts, offering a wide range of cannabis products including flower, pre-rolls, edibles, concentrates, vapes, and tinctures. The dispensary prides itself on providing high-quality products and excellent customer service to both recreational and medical users.
Medical patients skip recreational taxes, get higher purchase limits, and can shop at age 18+. Most people get approved online in about 20 minutes.
4.7
216 reviews
DeJa H
January 3, 2026
My first experience wasn't that great. I went to get a product for $25 ended up paying another $5i n taxes and $6 in ATM fees cause their POS system is considered an ATM. Had I known this in advance I would've paid cash. Never again, I'll stick with my local neighborhood peeps. That $11 is almost half a bag of another "product". Hell no
Kate Peterson
October 25, 2025
Favorite local spot. Great prices, the staff is helpful and friendly and they are always well stocked. Also a good spot for papers and accessories.
Zack Coleman
October 3, 2025
Great place and great service, Lexy was very helpful and nice and so was Ki. Great selection of products for a great price!! Highly recommend
Greg Hannum
October 2, 2025
Amherst location is great. 5 stars and kiana is a phenomenal budtender (sorry if I spelled your name wrong. Bonus points because they’re Red Sox fans
Amanda Coleman
September 16, 2025
At first I posted about the rso they did replace it had to wait for a manager that's all they replaced.it and it's one.of the best rso I had in a while. And I absolutely love my shark bowl you especially ordered for me. Highly recommend thank you all so much. Definitely love going in and seeing all the budtenders smiling and absolutely amazing customer service.
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Read about why every weed smoker needs one →
Levoit Core 300-P
143 CFM · 219 sq ft
$80–$110
Coway Airmega AP-1512HH
246 CFM · 361 sq ft
$160–$210
Austin Air HM400
400 CFM · 1,500 sq ft
$475–$595
Tourists 21+ can purchase recreational cannabis with valid ID. Same transaction limits apply. 253 Farmacy Weed Dispensary Amherst is a recreational & medical dispensary, so no medical card is needed for adult-use purchases.
In Massachusetts, recreational customers can purchase up to 1 oz of flower or 5g of concentrate per transaction. Can possess up to 10 oz at home.. 253 Farmacy Weed Dispensary Amherst may have additional product-specific limits — check with the dispensary for details.
253 Farmacy Weed Dispensary Amherst is cash only. Check with the dispensary for nearby ATM locations.
253 Farmacy Weed Dispensary Amherst does not currently list delivery as an option. Available options include in-store.
253 Farmacy Weed Dispensary Amherst is located at 328 College Street, Amherst, MA 01002. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
Medical patients in Massachusetts save ~20% on cannabis purchases, get higher purchase limits, and access dispensaries at age 18+. Most patients can get approved online in about 20 minutes.
✓ Board-certified physicians · ✓ 4.8★ rated · ✓ 500,000+ patients approved
Get My Massachusetts Medical CardLast updated January 15, 2026
Massachusetts legalized recreational cannabis in 2016 through Question 4. Retail sales began in November 2018. Adults 21+ can purchase from licensed retailers. Massachusetts has a medical program since 2012.
Recreational: 21+
Medical: 18+
Rec: 1 oz of flower or 5g of concentrate per transaction. Can possess up to 10 oz at home.
Med: 10 oz per 60 days
Prohibited in any public place or anywhere tobacco is banned. Private property with owner consent only.
Adults 21+ may grow up to 6 plants per person, 12 per household. Must be in a locked area.
Allowed
Recreational: 10.75% state excise tax plus 6.25% state sales tax plus optional 3% local tax. Medical: exempt from state taxes.
Tourists 21+ can purchase recreational cannabis with valid ID. Same transaction limits apply.
Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.
