T
Tamme Kelly
January 29, 2026
5.0
Really loved it. They’re very welcoming and friendly and helpful.
Medical$$
Cannabis Headquarters
4.9(238)
Cannabis Headquarters is a medical dispensary located in Mississippi, offering a wide range of cannabis products including flower, pre-rolls, edibles, concentrates, and vapes. They provide a selection of high-THC products and emphasize quality with various brands available.
Medical card required in Mississippi
Cannabis Headquarters is a medical-only dispensary. You must have a valid Mississippi medical marijuana card to purchase here. Get approved online in about 20 minutes.
Products & Menu
FlowerPre-RollsEdiblesConcentratesVapesAccessories
THC:25%–30%
CBD:0%–20%
Features & Amenities
Experience
💻Online Ordering
Fulfillment
🏪In-Store
Payment
💵Cash
Medical
🏥Accepts Medical Card
Access
♿Wheelchair Accessible
Hours
Monday8:00 AM – 12:00 AM
Tuesday8:00 AM – 12:00 AM
Wednesday8:00 AM – 12:00 AM
Thursday8:00 AM – 12:00 AM
Friday(Today)8:00 AM – 12:00 AM
Saturday8:00 AM – 12:00 AM
Sunday10:00 AM – 8:00 PM
Reviews (238)
4.9
4.9
238 reviews
C
Candace Duncan
January 21, 2026
5.0
Greda was great. I won a drawing and scored a coupon book. It's also a homemade comic book that she made. I freaking love it.
C
Courtney Carlisle
January 8, 2026
5.0
Greda was so fun to talk and had a great personality. She was super informativeabout the products, answered all of my questions leading me to learn something new about terpenes.😁 Great customer service I will definitely be back in the future.
K
Kevin & Janette
January 1, 2026
4.0
Tried this place for the first time and was pleasantly surprised. The products were all visibly displayed and the employee was very knowledgeable.
B
Brian Sherwood
December 21, 2025
5.0
I had a great experience and the prices were awesome but best of all was Gretta,she was extremely knowledgeable and helpful,definitely going back!!!
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Frequently Asked Questions About Cannabis Headquarters
Can tourists buy from Cannabis Headquarters?
Only Mississippi residents with a valid medical cannabis card may purchase. No out-of-state reciprocity. Cannabis Headquarters is a medical dispensary, so a valid medical card is required for purchases.
How much can you buy at Cannabis Headquarters?
In Mississippi, medical customers can purchase up to 3 oz per month (3.5g per day equivalent); terminally ill patients may purchase up to 6 oz per month. Cannabis Headquarters may have additional product-specific limits — check with the dispensary for details.
Is Cannabis Headquarters cash only?
Cannabis Headquarters is cash only. Check with the dispensary for nearby ATM locations.
Does Cannabis Headquarters offer delivery?
Cannabis Headquarters does not currently list delivery as an option. Available options include in-store.
What are Cannabis Headquarters's hours?
Cannabis Headquarters is located at 608 North Gloster Street, Tupelo, MS 38804. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
Get Your Mississippi Medical Card Online
You need a Mississippi medical marijuana card to purchase from dispensaries in this state. The whole process can be completed online in about 20 minutes from home.
✓ Board-certified physicians · ✓ 4.8★ rated · ✓ 500,000+ patients approved
Get My Mississippi Medical CardOther Dispensaries in Tupelo
Cannabis Laws in Mississippi
Last updated January 15, 2026
Mississippi legalized medical cannabis in 2022 through SB 2095 (the Mississippi Medical Cannabis Act). Licensed dispensaries began selling in early 2024. Recreational cannabis remains illegal.
Minimum Age
Medical: 18+
Purchase Limits
Med: 3 oz per month (3.5g per day equivalent); terminally ill patients may purchase up to 6 oz per month
Public Consumption
Prohibited. Medical cannabis may only be consumed at a private residence. Smoking is allowed for medical patients.
Home Growing
Not allowed.
Delivery
Not allowed
Tax Info
Medical cannabis is subject to a 7% state sales tax.
Visitor & Tourist Rules
Only Mississippi residents with a valid medical cannabis card may purchase. No out-of-state reciprocity.
⚠️
Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.