J Riley
January 18, 2026
Favorite shop in the city. I drive from Nashville to come here I know crazy but I have nothing better to do. Always great prices and even better staff! Five stars.

Key Cannabis Dispensary in Cape Girardeau, MO offers a wide selection of cannabis products for both medical and recreational users. Customers can enjoy a variety of options including flower, edibles, and extracts, with the convenience of online ordering and pickup in-store or via drive-thru.
25 South Kingshighway
Cape Girardeau, MO 63703
$$ · Recreational & Medical
Medical patients skip recreational taxes, get higher purchase limits, and can shop at age 18+. Most people get approved online in about 20 minutes.
4.7
714 reviews
J Riley
January 18, 2026
Favorite shop in the city. I drive from Nashville to come here I know crazy but I have nothing better to do. Always great prices and even better staff! Five stars.
Riley Wyatt
December 29, 2025
Cody was the most genuine budtender I have ever encountered. This was my first time at Keys and I will definitely be back!
Bill Minter
November 15, 2025
Awesome Service, Friendly smile and willingness to help me find what I was looking and helpful in being able to use.some.of.my loyalty points, been this locations several times and best Service ever!
Andrew Tice
October 6, 2025
Great customer service, very friendly staff. Their products are of great quality. If you don’t know what you’re looking for they will help with suggestions and the prices are very reasonable.
Kevin Casey Studios
September 25, 2025
I shopped there for the very first time. It was an amazing experience. The staff was very helpful. The product was very well reasonably priced and I’m very happy and will be shopping there on a regular basis.
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Tourists 21+ can purchase recreational cannabis with valid ID. Key Cannabis Dispensary Cape Girardeau is a recreational & medical dispensary, so no medical card is needed for adult-use purchases.
In Missouri, recreational customers can purchase up to 3 oz of flower per transaction. Key Cannabis Dispensary Cape Girardeau may have additional product-specific limits — check with the dispensary for details.
Key Cannabis Dispensary Cape Girardeau accepts cash as well as Debit, ATM On-Site. An ATM is available on-site.
Key Cannabis Dispensary Cape Girardeau does not currently list delivery as an option. Available options include in-store, drive-thru.
Key Cannabis Dispensary Cape Girardeau is located at 25 South Kingshighway, Cape Girardeau, MO 63703. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
Medical patients in Missouri save ~6% on cannabis purchases, get higher purchase limits, and access dispensaries at age 18+. Most patients can get approved online in about 20 minutes.
✓ Board-certified physicians · ✓ 4.8★ rated · ✓ 500,000+ patients approved
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Cape Girardeau, MO

Cape Girardeau, MO
Last updated January 15, 2026
Missouri legalized recreational cannabis in November 2022 through Amendment 3, with recreational sales beginning February 3, 2023. Adults 21+ can purchase from licensed dispensaries. Missouri also expunged past cannabis convictions as part of the amendment. Medical cannabis has been available since 2018.
Recreational: 21+
Medical: 18+
Rec: 3 oz of flower per transaction
Med: 6 oz per month
Prohibited in public places. Only allowed on private property with owner permission.
Medical patients may grow up to 6 flowering, 6 vegetative, and 6 clones/seedlings. Recreational home growing is allowed for adults 21+ with a personal cultivation license ($100).
Allowed
Recreational: 6% state excise tax plus 4.225% state sales tax plus local taxes. Medical: 4% state tax.
Tourists 21+ can purchase recreational cannabis with valid ID.
Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.