E
Evan Patrick
November 14, 2025
5.0
The staff are great, very helpful and friendly. They always hook me up with sweet deals, and I love the products here. This is my regular go to
RecreationalMedical$$
Root 66 Dispensary - Des Peres, MO
4.9(447)
Root 66 Dispensary in Des Peres, MO, offers a wide range of cannabis products for both medical and recreational users. Opened in September 2023, the dispensary is committed to providing excellent customer service and a welcoming atmosphere for all customers.
Save ~6%/yr with a Missouri medical card
Medical patients skip recreational taxes, get higher purchase limits, and can shop at age 18+. Most people get approved online in about 20 minutes.
Products & Menu
THC:10%–30%
CBD:0%–20%
🏷️ Deals & Discounts
Daily Specials
Features & Amenities
Fulfillment
🏪In-Store
Payment
💵Cash
Medical
🏥Accepts Medical Card
Shopper Type
💬Budtender Recs
Access
🅿️Parking♿Wheelchair Accessible
Deals & Discounts
📅Daily Specials
Hours
Monday8:00 AM – 10:00 PM
Tuesday8:00 AM – 10:00 PM
Wednesday8:00 AM – 10:00 PM
Thursday8:00 AM – 10:00 PM
Friday(Today)8:00 AM – 10:00 PM
Saturday8:00 AM – 10:00 PM
Sunday8:00 AM – 10:00 PM
Reviews (447)
4.9
4.9
447 reviews
E
Emily Richardson
October 25, 2025
5.0
Charlie was awesome and very knowledgeable when a friend and I went in to check out the inventory. Would recommend Root 66 to anyone!
E
Emily Walter
October 17, 2025
5.0
Honestly love this place it right by my work and the elevate 10 pack prerolls are amazing! Charlie helped me but anyone who helps out is fantastic!
m
monae cribbs
October 16, 2024
5.0
Come thru they’re awesome! Senia and Graham and Justin helped tremendously! Come say hi! Tell them Monae sent you but it won’t get you anything but whatever lol!!!
f
feranda smith
September 27, 2024
5.0
They’re friendly and efficient especially Andrew. They have a great selection and you can’t beat the cleanliness of the place. Definitely one of my go to dispensaries
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Frequently Asked Questions About Root 66 Dispensary - Des Peres, MO
Can tourists buy from Root 66 Dispensary - Des Peres, MO?
Tourists 21+ can purchase recreational cannabis with valid ID. Root 66 Dispensary - Des Peres, MO is a recreational & medical dispensary, so no medical card is needed for adult-use purchases.
How much can you buy at Root 66 Dispensary - Des Peres, MO?
In Missouri, recreational customers can purchase up to 3 oz of flower per transaction. Root 66 Dispensary - Des Peres, MO may have additional product-specific limits — check with the dispensary for details.
Is Root 66 Dispensary - Des Peres, MO cash only?
Root 66 Dispensary - Des Peres, MO is cash only. Check with the dispensary for nearby ATM locations.
Does Root 66 Dispensary - Des Peres, MO offer delivery?
Root 66 Dispensary - Des Peres, MO does not currently list delivery as an option. Available options include in-store.
What are Root 66 Dispensary - Des Peres, MO's hours?
Root 66 Dispensary - Des Peres, MO is located at 12095 Manchester Road, Des Peres, MO 63131. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
Get Your Missouri Medical Card Online
Medical patients in Missouri save ~6% on cannabis purchases, get higher purchase limits, and access dispensaries at age 18+. Most patients can get approved online in about 20 minutes.
✓ Board-certified physicians · ✓ 4.8★ rated · ✓ 500,000+ patients approved
Get My Missouri Medical CardCannabis Laws in Missouri
Last updated January 15, 2026
Missouri legalized recreational cannabis in November 2022 through Amendment 3, with recreational sales beginning February 3, 2023. Adults 21+ can purchase from licensed dispensaries. Missouri also expunged past cannabis convictions as part of the amendment. Medical cannabis has been available since 2018.
Minimum Age
Recreational: 21+
Medical: 18+
Purchase Limits
Rec: 3 oz of flower per transaction
Med: 6 oz per month
Public Consumption
Prohibited in public places. Only allowed on private property with owner permission.
Home Growing
Medical patients may grow up to 6 flowering, 6 vegetative, and 6 clones/seedlings. Recreational home growing is allowed for adults 21+ with a personal cultivation license ($100).
Delivery
Allowed
Tax Info
Recreational: 6% state excise tax plus 4.225% state sales tax plus local taxes. Medical: 4% state tax.
Visitor & Tourist Rules
Tourists 21+ can purchase recreational cannabis with valid ID.
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Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.