Root 66 Dispensary in St. Peters, MO, is a community-focused cannabis retailer offering a wide variety of products including flower, vapes, concentrates, and edibles. Open 24/7, they cater to both medical patients and recreational users, ensuring a welcoming experience for all customers.
3004 South Saint Peters Parkway
Saint Charles, MO 63303
$ · Recreational & Medical
Medical patients skip recreational taxes, get higher purchase limits, and can shop at age 18+. Most people get approved online in about 20 minutes.
4.7
719 reviews
Zavion Delgado
January 30, 2026
My friend just spent 120 dollars and he gets home to realize he's missing part of the order. Not that big of a deal but for time and effort to come back for a 30 minute roundtrip he can't get no courtesy compensation. Id just recommend somewhere else.
Spooky Sock
January 26, 2026
This place always has amazing deals and great service. It's near my house so I come here often and every single budtender knows their stuff and is super helpful. Love the product and the staff!
Leslie E H
January 20, 2026
This place seems like it’s a nice clean luxury type dispensary and it’s open 24 hours. What more could you ask for? If you go in person you will find the staff is not welcoming nor pleasant. The vibe is off. Their website information is incorrect. And if it’s below freezing like it has been, better hope you don’t have to go to the walk up window where they don’t require a preorder. There is no heart behind this business.
Sabrina Boland
December 25, 2025
Love this location and the people. My 1st experience was using the pre-order/window option, which I loved. It was quick and friendly. Since that time, I have been in the store, and was happy with the customer service and the available products. Maybe define the 'areas of service' with more distinct signage?
Alexia Devine
November 26, 2025
I had an amazing experience at Root 66! Raven, the floor manager, was incredibly helpful and really took the time to break down the rewards program and explain the quality of their products. The vibes are always great here—good energy, good people, and consistently excellent customer service. Shoutout to Amaze and Joshua as well for being so attentive and making the visit even better. Highly recommend this dispensary!
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Tourists 21+ can purchase recreational cannabis with valid ID. Root 66 Dispensary - St. Peters, MO is a recreational & medical dispensary, so no medical card is needed for adult-use purchases.
In Missouri, recreational customers can purchase up to 3 oz of flower per transaction. Root 66 Dispensary - St. Peters, MO may have additional product-specific limits — check with the dispensary for details.
Root 66 Dispensary - St. Peters, MO is cash only. Check with the dispensary for nearby ATM locations.
Root 66 Dispensary - St. Peters, MO does not currently list delivery as an option. Available options include in-store.
Root 66 Dispensary - St. Peters, MO is located at 3004 South Saint Peters Parkway, Saint Charles, MO 63303. The dispensary is open 7 days a week. Hours vary by day — check the hours section above for today's schedule.
Medical patients in Missouri save ~6% on cannabis purchases, get higher purchase limits, and access dispensaries at age 18+. Most patients can get approved online in about 20 minutes.
✓ Board-certified physicians · ✓ 4.8★ rated · ✓ 500,000+ patients approved
Get My Missouri Medical CardLast updated January 15, 2026
Missouri legalized recreational cannabis in November 2022 through Amendment 3, with recreational sales beginning February 3, 2023. Adults 21+ can purchase from licensed dispensaries. Missouri also expunged past cannabis convictions as part of the amendment. Medical cannabis has been available since 2018.
Recreational: 21+
Medical: 18+
Rec: 3 oz of flower per transaction
Med: 6 oz per month
Prohibited in public places. Only allowed on private property with owner permission.
Medical patients may grow up to 6 flowering, 6 vegetative, and 6 clones/seedlings. Recreational home growing is allowed for adults 21+ with a personal cultivation license ($100).
Allowed
Recreational: 6% state excise tax plus 4.225% state sales tax plus local taxes. Medical: 4% state tax.
Tourists 21+ can purchase recreational cannabis with valid ID.
Disclaimer: Cannabis laws change frequently. This information was last updated on January 15, 2026. Always verify current laws with official state sources before making any decisions. This guide is for informational purposes only and does not constitute legal advice.
